Home » Pnh and the GPI-Linked Proteins by Neal S. Young
Pnh and the GPI-Linked Proteins Neal S. Young

Pnh and the GPI-Linked Proteins

Neal S. Young

Published March 10th 2000
ISBN : 9780127729404
Hardcover
279 pages
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 About the Book 

Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctiveMoreParoxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients.Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.Key Features* Outlines the chemical features of PNH* Explains the mechanism of hemolysis* Includes work on the biochemistry of glycophosphoinositol anchors* Contains descriptions of the chemistry and biophysics of GPI-anchored proteins